26 September 2018: Global Protein
Kinase Inhibitor Market is anticipated to grow at a higher CAGR
in the forecast period. The global market encompasses extensive R&D and
favorable funding from private sector that propels the market growth.
Generally, a protein kinase is a kinase enzyme that alters other proteins by
chemically addition of phosphate groups to them. Protein kinases are
indispensable for various cell processes. These enzymes catalyze
phosphorylation of various other cellular substrates. Phosphorylation regulates
cellular functions in return. However, protein kinases can be deregulated under
pathological conditions resulting into variations in phosphorylation and
uncontrolled cell division, apoptosis inhibition and other abnormalities.
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Clinically, protein kinases help
in understanding inter and intra-cellular molecular interactions, and also
explains the role of multiple cellular biochemical networks and clarify unknown
details of different cell processes such as division and metabolism.
Characteristically, protein kinase inhibitors are chemically assorted and
possess low-molecular weight. Along with protein kinases with ATP substrate,
there exists a group of ATP non-competitive inhibitors which describe a group
of peptide inhibitors of protein kinases.
On a commercial scale, protein
kinase inhibitors help in diagnosing cancer patients and also the rise in
demand for custom treatments has been a prime feature in the growth of protein
kinase inhibitor market. Overall, with the product innovation and novel
therapies the protein kinase market is expected to rise at a higher CAGR in the
international market. Protein kinase inhibitor industry is driven by
factor such as rising R&D activities against cancer in developed countries.
Additionally, technological innovations and data-driven customizations to
fulfill consumer demand for efficiency and accurate outcome also propel the
market growth in the forecast period. Moreover, protein kinases as anti-cancer
drugs account for a significant share in the global market.
Protein Kinase inhibitor industry
geographically spans North America, Latin America, Asia-Pacific, Europe,
Middle-East and Africa. North America dominates the global market in terms of
value. Also, factors such as rising R&D activities in this region propel
the market growth in the forecast period. Europe is anticipated to rise at a
tremendous CAGR in the forecast period owing to extensive research on cancer
and cancerous cells.
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APAC regions are anticipated to
rise at a higher CAGR in the forecast period owing to rising prevalence of
cancer and need for novel therapies. Middle-East and African protein kinase
inhibitor industry is expected to rise at a moderate CAGR owing to low medical
infrastructure and less R&D activities.
The key players in the protein
kinase inhibitor industry include Pfizer, Alnylam Pharmaceuticals, Allergan,
Amgen, Biocon, Angstorm Pharmaceuticals, Bionomics, Acceleron Pharma, CASI
Pharmaceuticals, Celegene Corporation, Enzon Pharmaceuticals, Five Prime
Therapeutics, Fujifilm Kyowa Kirin Biologics, Hetero Drugs, Genentech, ImClone
Systems, Genexine, Intas Pharmaceuticals, Kyowa Hakko Kirin, Levolta
Pharmaceuticals, Marsala Biotech, Neumedicines, Novartis, Onyx Pharmaceuticals,
and Oncobiologics.
EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM), which inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM), prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. KYL
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